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CRACKING CANCER ANEUPLOIDY

Our lab focuses on a unique, understudied trait of cancer. Changes in the chromosomal composition of the cell, also known as aneuploidy, make for a fundamental difference between normal and cancer cells. We combine experimental and computational approaches to uncover the basic biology underlying this hallmark of cancer, track its origins and understand its cellular consequences. By doing so, we strive to expand our understanding of the genetic basis of cancer, and to make aneuploidy a therapeutic target for precision cancer medicine.

 

OUR RESEARCH INTERESTS

 
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CANCER ANEUPLOIDY

Aneuploidy – the presence of an abnormal number of chromosomes in cancer cells — is characteristic of most tumors, and is rarely observed in normal tissues. It is not fully understood how aneuploidy contributes to tumor formation and progression. Moreover, there are currently no therapeutics that target this hallmark of cancer to  eliminate tumors. We apply a variety of genomic and functional approaches to studying this phenomenon.

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EVOLUTION OF CANCER MODELS

The study of the complex genetics of human cancer depends on reliable cancer model systems. However, these models reflect the biology of actual human tumors only to a certain extent, and they evolve in ways that pose both risks and opportunities for cancer research. We study the genomic stability and evolution of cancer model systems, in order to improve their use in basic research, with an emphasis on aneuploidy research.

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STEM CELLS & CANCER

Human stem cells share fundamental characteristics with human cancer cells, and thus make for a unique model system for the study of cancer genetics. We use human stem cells as a tool for aneuploidy research, taking advantage of their inherent chromosomal instability and of their amenability to genome editing.  We also use human stem cells as a tool for the identification of cancer vulnerabilities.

 

OUR BIG QUESTIONS

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WHAT DRIVES ANEUPLOIDY IN CANCER? HOW DOES ANEUPLOIDY CONTRIBUTE TO THE INITIATION AND PROGRESSION OF TUMORS?

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WHAT CELLULAR VULNERABILITIES ARE INDUCED BY ANEUPLOIDY? HOW CAN ANEUPLOIDY BE EXPLOITED TO KILL CANCER CELLS?

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WHAT ARE THE IMPLICATIONS OF GENOMIC EVOLUTION FOR CANCER MODELING? HOW CAN CANCER MODEL SYSTEMS BE IMPROVED?

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LAB NEWS

CONGRATULATIONS TO HAJIME FOR BEING AWARDED THE JSPS OVERSEAS RESEARCH FELLOWSHIP!

October 30, 2022

CONGRATULATIONS TO YAEL FOR BEING AWARDED THE FACULTY OF MEDICINE "EXCELLENCE IN RESEARCH" AWARD!

September 16, 2022

WELCOME TO ADI, WHO HAS JOINED THE LAB AS A SUMMER STUDENT!

August 1, 2022

OUR COLLABORATIVE STUDY WITH THE BARZEL AND MADI LAB JUST PUBLISHED IN NATURE BIOTECHNOLOGY -- FIND IT HERE AND READ ABOUT IT IN 'HAARETZ'!

June 30, 2022

WELCOME TO HAJIME, WHO IS JOINING THE LAB AS A POSTDOC!

June 20, 2022

CONGRATULATIONS FOR YOUR WEDDING, TOM & OR!!!

May 27, 2022

April 1, 2022

OUR NEW RESEARCH ARTICLE -- WHOLE-GENOME DUPLICATION SHAPES THE ANEUPLOIDY LANDSCAPE OF HUMAN CANCERS -- IS OUT IN CANCER RESEARCH. CHECK IT OUT HERE.

February 23, 2022

WELCOME TO RACHEL, WHO HAS JOINED THE LAB AS AN M.SC. STUDENT

February 20, 2022

MICHAL'S PAPER ACCEPTED TO NPJ PRECISION ONCOLOGY, AND HER RELATED AVODAT GMAR GOT THE GRADE 100 (!) -- CONGRATULATIONS!

February 15, 2022

December 14, 2021

URI WAS SELECTED AS AN EMBO YOUNG INVESTIGATOR. READ ABOUT IT HERE AND HERE. CONGRATULATIONS!

December 6, 2021

THE BEN-DAVID LAB HAS BEEN AWARDED THE FORBECK ACCELERATOR GRANT

November 1, 2021

THE BEN-DAVID LAB HAS BEEN AWARDED THE ISRAEL PRECISION MEDICINE PARTNERSHIP (IPMP) RESEARCH GRANT, IN COLLABORATION WITH PROF. ITTHAI BEN-PORATH AND DR. AMIR SONNENBLICK.

October 7, 2021

WELCOME TO NIR, WHO HAS JUST JOINED THE LAB AS A POSTDOCTORAL FELLOW!

October 3, 2021

OUR NEW PREPRINT IS OUT. IN COLLABORATION WITH THE BARZEL AND MADI LABS, WE DISCOVERED A SURPRISINGLY HIGH PREVALENCE OF ANEUPLOIDY IN HUMAN T CELLS EDITED BY A CLINICAL CRISPR PROTOCOL. CHECK IT OUT HERE.

August 21, 2021

WE'RE HAPPY TO WELCOME TO THE LAB ANOUK  SAVIR-KADMON AND TAL BEN-YISHAY AS SUMMER INTERNS!

August 1, 2021

THE ISF HAS AWARDED THE BEN-DAVID LAB THE ISF RESEARCH GRANT AND THE ISF NEW FACULTY EQUIPMENT GRANT!

July 27, 2021

WELCOME TO THE LAB, YONATAN AND LINOY!

June 27, 2021

NEW GRANTS AWARDED TO THE LAB:
* THE FORBECK FOUNDATION COVID RECOVERY GRANT

* THE SCHREIBER FOUNDATION RESEARCH GRANT
* THE SHTACHER AWARD

February 25, 2021

OUR NEW STUDY ON ANEUPLOIDY-INDUCED VULNERABILITIES JUST PUBLISHED IN NATURE! YOU CAN READ IT HERE.

January 27, 2021

OUR NEW PREPRINT ON THE GENOMIC EVOLUTION OF PDXS IS OUT -- READ IT HERE.

January 18, 2021

CHECK OUT DR. BEN-DAVID'S POPULAR SCIENCE TALK AT THE ICRF WEBINAR SERIES

January 14, 2021

OUR PAPER ON "ANEUPLOIDY-INDUCED CANCER VULNERABILITY TO MITOTIC CHECKPOINT INHIBITION" HAS BEEN ACCEPTED TO NATURE! CONGRATS!

Nov 19, 2020

CONGRATS TO MICHAL AND TO KAVYA, FOR SHARING THE SECOND PRIZE OF THE "BEST POSTER AWARD" OF THE SAFRA BIOINFORMATICS RETREAT!

Nov 4, 2020

CONGRATULATIONS TO TOM AND TO GIL, FOR OFFICIALLY STARTING THEIR PHD PROGRAM!

Oct 1, 2020

THE BEN-DAVID LAB IS AWARDED THE ERC STARTING GRANT! SEE HERE FOR THE PRESS RELEASE.

September 03, 2020

DR. BEN-DAVID IS AWARDED THE ICRF GESHER AWARD!

August 21, 2020

DR. BEN-DAVID (TAU) AND DR. AMON (MIT) ARE AWARDED A JOINT BSF RESEARCH GRANT!

July 26, 2020

OUR CAS9/P53 ARTICLE IS FEATURED ON THE COVER OF NATURE GENETICS THIS MONTH! CHECK IT OUT HERE.

July 7, 2020

THE BEN-DAVID LAB IS AWARDED THE DOD CANCER RESEARCH PROGRAM CAREER DEVELOPMENT AWARD!

June 22, 2020

DR. BEN-DAVID IS AWARDED THE 2020 'NEXT GEN STAR' AWARD OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR)

March 1, 2020

WATCH DR. BEN-DAVID'S TALK AT:

WORLD CANCER DAY, 2020

February 3, 2020

 

RESEARCH FUNDING

 
 

ADDRESS

Faculty of Medicine, Room 728
Tel Aviv University
P.O.B 39040
Ramat Aviv, Tel Aviv 69978

CONTACT


ubendavid@tauex.tau.ac.il

+972-(0)73-3804730

+972-(0)54-6004444